General Method Description

Wolf bones became valuable when Summoning was introduced to RuneScape, as they are a component in both a low-level and high-level pouch. Most players kill wolves for their bones at White Wolf Mountain, but it is actually somewhat faster to kill lower level wolves on the top level of the Stronghold of Security.

Low level players can kill the wolves continuously, but higher level players can kill the wolves very quickly so their slow respawn rate becomes the limiting factor on kill speed; you can take advantage of this extra time by also killing minotaurs in the same room. The minotaurs mostly have poor drops but do provide iron arrows that don't take inventory space, and even better, 15 noted pure essence at a time!

With level 50 skills your combat level should be above the 55 needed to avoid the level 27 minotaurs being aggressive, so I recommend going to the far southeast room in the dungeon, where there are level 11 wolves that are faster to kill.

Use a spirit terrorbird or better to carry extra drops.