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Crawling hands or various zombies, depending on assignment
Zombie Hand - Access and Combat Recommendations
Access Directions
Zombie hands are located in a pair of rooms near the middle of the long tunnel that connects Canifis and Meiyerditch.
The fastest way to get here is using a teleport tablet to the blood Runecrafting altar, but this is only obtainable as a minigame reward from the Great Orb Project. Other than that, the fastest way to get here is to access the Abyss via the Zamorak mage north of Edgeville. Go through the blood altar rift and then exit the ruins; follow the trail east and then south; the hands are on the east side once the trail turns south.
If you don't want to go into the Abyss (which involves the risk of revenants and drains your prayer) there's a shortcut you can take from Canifis. This requires level 65 Agility. It is the method I personally prefer as I don't like the Abyss. Go down the trap door behind the bar as if going to Mort'ton, then take the first cave entrance. Go due south past the tomb of Ivandis and you'll find a connection to the tunnel to Meiyerditch. Walk through the serpentine tunnel until you get to the jutting wall and pass it. Continue along the long tunnel until you get to the room of skeletal and zombie hands on the east side.
Equipment
Standard melee gear, rune or better, is sufficient for higher-level players. Mid-levels may wish to wear Barrows; Guthans could be helpful.
If cannoning, you'll be under constant attack so wear prayer gear.
Supplies
Bring an inventory of food for healing, and consider bringing Bones to Peaches tablets or runes if you're lower level or are staying for a long time.
Super sets are advised to speed up kills and reduce food use.
Bring several prayer potions if using a cannon, in addition to the cannon and cannonballs, of course.
These monsters drop many alchable items. I recommend at least 40 sets of alching runes per hour, or 100 if using a cannon!
Familiar
A beast of burden is extremely useful here, as these monsters drop many unnoted items and the extra space lets you better juggle supplies and drops and bring home more items of value. Since the area is multicombat, a combat familiar is another option, but it doesn't make a great deal of difference in practice.
Combat Notes
These monsters are easy to kill, it just takes a while because they have 1000 LP. Relatively high level players will only use a small amount of food.
Watch out for sneak attacks by burrowing skeletal hands -- most are unaggressive, but if you look on the ground you'll see what appear to be largish lumps - these are aggressive and you cannot attack them until they come after you. They are also in the tunnels.
In most cases you will fight zombie hands in combination with Skeletal Hands; in fact, because of those aggressive skeletal hands, you can't really fight only the zombie hands -- that doesn't matter much, though.
This is a very effective place for cannoning; you can get a lot of XP and a large collection of drops from both these and the Skeletal Hands in the same room.
Drop Notes
In keeping with their "hand" motif, these monsters drop large quantities of bracelets -- plain, gem-filled and enchanted. Most of these should be alched in place, but some are worth bringing back to sell.
These hands also drop decent quantities of strawberry, sweetcorn, belladonna and limpwurt seeds, and small numbers of combination runes. You can also get a crawling hand drop from them (to stuff for your player-owned house).
Another interesting fact is that these are one of the few non-boss monsters in the game that drops only high level herbs, as well as grimy toadfax.
I must admit that the dragonstone bracelet was a bit of a surprise to me! I'm not sure which type of hand dropped it, but since their other drops are identical, I assume both are capable of it (rarely).